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A subgroup analysis of patients consistent with the current US Prescribing Information (USPI) from HEROES was also performed, which excluded contraindications of OCA (ie, compensated cirrhosis with evidence of portal hypertension)

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Only a small percentage, approximately 12%, adopts the reduced form, which is characterised by a free thiol group (Hcy-SH) [60] (Figure 3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 373.Song Y., Qi H., Wu C

Superoxide dismutase 1 (SOD1) was previously identified as the molecular target of LCS1, demonstrating the utility of this approach for defining new dependencies in LUAD cells (11)

To evaluate the biological relevance of the docking pose, it is important to determine whether the docking pose is consistent with known biological data and if it is likely to be biologically active