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Concerning histone modifications, granulosa cells from PCOS patients exhibit enhanced histone deacetylase (HDAC) activity, which decreases acetylation levels of pro-inflammatory cytokines ( e.g ., TNF-, IL-6) and suppresses their transcriptional activation

3.2.3.3 Immunometabolic regulation of cytokine networks The cytokine profile in the TME precisely regulates the interaction between ferroptosis and ICD by shaping the pro-inflammatory/anti-inflammatory balance