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Eosinophil-driven glucose depletion impeded protective Th1 immune responses

Methylation of CpG islands in the promoter region suppresses gene expression, as 5-methylcytosine interferes with the binding of transcription factors or other DNA-binding proteins causing reduced transcription

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This results in an overproduction of pro-inflammatory cytokines such as interleukin 6 (IL-6), tumour necrosis factor , adhesion molecules, prostaglandins, and mitogen-activated protein kinase signalling cascades

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