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Nature 406, 775781

THE ROLE AND EVOLUTION OF SUPEROXIDE DISMUTASES IN ALGAE

Oxidative stress caused by ROS overproduction can contribute to the pathogenesis of IBD by damaging cellular components, activating proinflammatory signaling pathways, and impairing the intestinal epithelial barrier

Specifically, targeting oxidative stress through molecular pathways such as MAPK, TLR4/NF-B, Nrf2, and PI3K/Akt could offer new therapeutic avenues for IBD management