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Funding This work was supported by the Projects of Medicine and Health Science Technology Development Program in Shandong Province [2016WS0499], Shandong Provincial Natural Science Foundation of China Grants [ZR2019PH025]

Conversely, in these UM populations the prodrug codeine (another CYP2D6 substrate) is metabolized much faster to morphine, often resulting in undesirable adverse effects of morphine, such as abdominal pain

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