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Gu et al

To enhance the effectiveness of phytochemical labeling, it is essential to include the effects of various matrix structures (such as hydrogels, oleogels, and emulsions) in the literature, as these structures significantly influence the solubility of phytochemicals due to their hydrophilic and lipophilic properties

Goshajinkigan (GJG), a traditional Japanese herbal medicine, has been evaluated in a randomized controlled trial showing that (GJG) has a neuroprotective effect and nerve-repairing effect in CIPN [60]

The mature adipocytes secrete BMP4 that triggers preadipocyte differentiation by inducing the separation of Wnt1 inducible-signaling pathway protein 2 (WISP2) and zinc finger protein 423 (ZNF423), allowing ZNF423 to translocate into the nucleus and activate peroxisome proliferator-activated receptors (PPAR) and downstream cascade including CCAAT/enhancer-binding proteins (C/EBP), , and [41, 42] ( Figure 1 )

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Mechanistically, we attributed the observed phenotype to impaired LXR alpha, PPAR gamma, and glucocorticoid receptor (GR) signalling