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Consistently, compared to EPOP WT , the PRC2-binding-defective mutant EPOP D5 did not alter nucleosome binding by PRC2.1 MTF2 in a biotinylated mononucleosome pull-down assay (Supplementary Fig

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They trigger an inflammatory response that activates macrophages and neutrophils ( and H 2 O 2 during the pathogenesis of endometriosis ( and H 2 O 2 produced by these inflammatory responses in the peritoneal, ovarian and oviductal environments of endometriomal implants are significantly higher than those which are generally encountered in their healthy counterparts ( Pernicious effects of refluxed blood and the balance of pro-oxidant and antioxidant forces: the fenton reaction In addition to inflammatory components, accumulated refluxed menstrual blood contains numerous lysed erythrocytes

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Patients with inflammatory bowel disease, diverticular disease, haemorrhoids, recent colorectal surgery, cardiovascular conditions, pregnancy, severe renal or cardiac impairment, coagulopathy, or recent pelvic radiotherapy face heightened risks