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Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury

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Acetaldehyde and ROS generated during alcohol metabolism can directly stimulate KCs and HSCs, promoting the transcription and secretion of TNF- [124, 125]

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To further increase the ERG yield, we focused next on reinforcing the sulfur metabolic flux toward ERG biosynthesis, because this pathway was indicated to be the rate-limiting pathway in our previous study 26