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Emerging evidence indicates marked differences between primary and metastatic lesions in terms of metabolite composition, mitochondrial activity, ROS levels, and the architecture of the tumor microenvironment [17,18,19,20]

10 In instances where thiopurine therapy is not tolerated, is contraindicated or, increasingly, is not preferred because of its increased risk of infections and certain malignancies, the use of advanced therapies for ongoing maintenance therapy following steroid induction is indicated

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