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Simultaneously, prolactin can alter the expression of lipidogenesis genes in subcutaneous white adipose tissue and exacerbate glucose intolerance induced by a high-fat diet ( 4.3 Insulin resistance and glucose metabolic dysregulation Clinical, epidemiological, and experimental studies have consistently shown that hyperprolactinemia is strongly associated with glucose metabolism disorders that primarily manifest as insulin resistance and impaired glucose tolerance

Peripheral administration and AAV-mediated liver expression of brain-penetrant PGRN biologics have been shown to rescue phenotypes of Grn / mice and Grn / Tmem106b / DKO mice, respectively [197, 210]

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Martnez-Pinilla, Nutrients 5 (2013) 41594173

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