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For this reason, NF-B not only induces DNs in the SN but also increases the PD severity through the accumulation of A 1-42 and -synuclein

doi: 10.1039/c0mt00006j

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This strategy suits users who plateau after several months suggesting diminishing returns, want to minimize long-term costs while maintaining some benefits, prefer avoiding indefinite commitments to any treatment, notice maintained improvements during initial breaks suggesting cycling viability, and value flexibility over maximum continuous optimization