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Wortelboer HM, Balvers MG, Usta M et al (2008) Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2

manipulated extracellular matrix remodeling thereby increased vessel compliance to alleviate arterial stiffness through suppressing MMP2, MMP9 and TGF-, inactivated energy sensor AMPK1 to block energy supply, relived ROS overeaccumulation mediated mitochondrial dysfunction, restrained cell pyroptosis to alleviate vascular inflammation in PVR by the inhibition of HSP47, NLRP3, caspase 1, IL-1 and IL-18

In practice, many supervised protocols combine these approaches

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Post-chemotherapy-persister cells resistant to lapatinib treatment in breast, melanoma, lung, and ovarian cancer have been characterized as GPx4-dependent (63)