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Diabetes mellitus, which is a complication of obesity, can activate satellite glial cells of the supracervical ganglia through P2Y receptors, resulting in increased expression of pro-inflammatory cytokines such as IL-1, and causing oxidative damage to the autonomic nerves such as via an inflammatory response (111, 112) ( Figure 2 )

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9,13 Other mechanisms of hepatotoxicity include the formation of toxic free radicals, such as peroxynitrite, from the reaction of superoxide and nitric oxide, subsequently forming nitrotyrosine adducts inside the mitochondria

Skin color results from pigment (melanin granules) in keratinocytes and melanocytes in superficial skin layers

Drawing exactly 12.5 units requires estimating the halfway point between markings