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5,6,30,31 Moreover, increasing number of prospective cohort studies and meta-analyses demonstrate that exercise reduces mortality and cardiovascular events

2 Ferroptosis: molecular features and its relevance in atherosclerosis Ferroptosis, a form of iron-dependent programmed cell death identified in 2012, is characterized by the accumulation of lipid hydroperoxides, ultimately leading to cellular damage and death ( The classical ferroptosis pathway is regulated by the Cystine/GSH/GPX4 axis

It does this through the process of detoxification, promoting the excretion of naturally-produced and externally-consumed compounds that lead to oxidative stress such as chemical pollutants, atmospheric pollutants, and alcohol

Clin Cancer Res 15(1):267-273, 2009

Energy metabolism: the glucose-lactate shuttle Over the past decade, our thinking of neuroenergetics has changed from a neuron-centric viewpoint to a neuron-astrocyte cooperation perspective

In contrast, the GSTM*A and GSTM*B polymorphisms are associated with the C519G substitution (asparagine is substituted with lysine at position 173.7), while the lack of scientific evidence for a functional difference between these polymorphisms means that they are classified together as phenotype 7