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doi: 10.3390/antiox13060702

ROS cause a decrease in tissue inhibitors of metalloproteinases (TIMPs), thus resulting in high levels of metalloproteases (MMPs)

Next, the GSH linked with the active site cysteine residue of OsDHAR (enzyme-S-S-G) is removed by nucleophilic attack of the H-site bound GS

In personalized therapy-focused clinical trials, the adoption of a scoring system based on tumor mutational burden (TMB) emerged as a potential biomarker, correlating with improved overall survival (OS) in cases of toripalimab-treated chemorefractory GC 6