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In CKD patients, reduced corin expression in the kidney and decreased urinary soluble corin levels have been reported [58] whereas its overexpression in the UUO model attenuated fibrosis progression [59]

FIGURE 6 The COVID-19 pandemic, caused by the 2019 novel coronavirus, is spreading globally

Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro

Gut microbiota dysbiosis can also induce an inflammatory response and affect the metabolism of bile acids (BAs), short-chain fatty acids (SCFAs), trimethylamine-N-oxide (TMAO) and other bioactive molecules, resulting in systemic inflammation and endothelial dysfunction

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To maintain the benefits, regular maintenance shots or continued infusions are necessary