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For example, an endogenous lymph node-targeted lipid nanoparticle 113-O12B shows higher and more specific expression in the lymph node (LN), and LN-directed delivery of mRNA enhances the CD8 + T cell response to the full-length ovalbumin model antigen and improves antitumor efficacy (172)

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102 SabatiniS.BeisD.WolkenfeltH.MurfettJ.GuilfoyleT.MalamyJ.et al (1999)