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The authors mutated residues in the orthosteric binding pocket of OR and tested the abilities of those mutants to activate G protein signaling and -arrestin recruitment by fentanyl, morphine, and DAMGO, respectively

Cikutovic M, Fuentes N, Bustos-Obregn E

K.Nutile-McMenemyN.HarrisB

& Pedersen, B

Der Rest bleibt im Darm und wird je nach Zusammensetzung der Darmflora zu anderen Produkten umgebaut, die nicht immer harmlos sind (zum Beispiel Trimethylamin-N-oxid)