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Immunologically active substances, including natural active compounds, small molecule compounds, and repurposed drugs, have achieved satisfactory results in vitro experiments, animal experiments, or clinical trials

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The swelling of mitochondria, the dilatation of intercellular space and the dilatation of inner plasma can be seen clearly in electron microscope (9)

Furthermore, Ca 2+ -dependent C2 membrane binding disrupts C2/HECT interactions, but not Ca 2+ alone, whereas 14-3-3 protein binds to a flexible region of Nedd4-2 containing the WW2 and WW3 domains, thereby inhibiting its catalytic activity and membrane binding

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In future research, more detailed inclusion criteria should be formulated for clinical trials to reduce the incidence of adverse reactions