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Puranam and Attardi, 2001

These symptom improvements were detected after the first 10 days of intramuscular treatment and persisted throughout the 4-month treatment period

Standard interventions include dietary branched-chain amino acid restriction to limit precursor influx, Cbl supplementation in vitamin B12-responsive patients to augment residual MMUT activity, carnitine administration to promote propionylcarnitine excretion, and betaine supplementation to promote Hcy remethylation