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The RIP1 pathway was also shown to contribute specifically to the promotion of oxidative stress-induced necroptosis, which leads to melanocyte death

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[7] It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulfide bond

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In this review, we first address the mechanistic principles of ROS generation, signaling and detoxification across key cellular compartments

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