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Regular consumption of grapefruit can brighten the skin, even out complexion, and protect against premature aging

As an effector molecule, NO participates in antimicrobial responses and cooperates with oxidative stress processes to amplify inflammatory signaling, thereby being associated with an M1-like pro-inflammatory program ( + macrophage-like state with immunoregulatory features in mouse macrophage models ( In addition to generating terminal effector molecules, Arg metabolism can also influence inflammatory transcriptional programs through metabolic-signaling coupling

10.1016/j.jconrel.2020.04.026 83 ZhangX.ChenX.JiangY.-W.MaN.XiaL.-Y.ChengX.et al (2018)

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