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Additionally, 12 weeks of swimming exercise in ApoE / mice resulted in attenuated weight gain, improved arterial structural integrity, and reduced atherosclerotic lesion burden, accompanied by decreased serum concentrations of total cholesterol (TC), TG, soluble intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), and interleukin-6 (IL-6), collectively mitigating the progression of atherosclerosis ( In summary, exercise is well-established to alleviate atherosclerosis by modulating blood lipid profiles, reducing CIMT, and mitigating inflammation, thereby providing a robust foundation for non-pharmacological intervention. The alleviation of atherosclerosis through exercise involves an extremely complex molecular mechanism