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In addition, the concentrations of proinflammatory cytokines, such as IL-17 and TNF-, were significantly increased, whereas those of several anti-inflammatory cytokines and chemokines, such as IL-1ra, IL-7, and MIP-1, were distinctly reduced in the plasma of MS patients compared with those in healthy subjects

This microenvironment is of extreme importance due to its role not only as a structural, modifiable, and flexible scaffold for cells but also as a provider of a range of biochemical and biophysical signals that collectively regulate cell behaviors such as spreading, proliferation, migration, differentiation, and apoptosis [87]

S-L, low expression of SEC63-tag

Challenges remain, requiring further research for successful clinical translation

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