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Platelet IIb3 receptor-mediated platelet activation is the final common pathway of receptor-mediated platelet activation, including GPVI, T X A 2 , P2Y1 and P2Y12, and recent studies have demonstrated that fibrinogen and fibronectin can also activate GPVI, which in turn enhances platelet activation and thrombosis ( Increased platelet ROS is strongly associated with thrombophilia, hypertension, diabetes, hypercholesterolemia, and metabolic syndrome ( in vitro

Figure 3 : A protein molecule surrounded by a mesoscopic sphere of water molecules Variations in the number of dissolved solute molecules (e.g., proteins) in a solvent can lead to the generation of high osmotic pressures at aqueous interfaces [Chaplin, 2014], particularly ion-exchange and uncharged hydrophilic surfaces

Biomolecules & therapeutics, 33(1), 117128

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