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Description

Mechanistic studies indicate that it can regulate the PTEN/Akt/GSK-3/-catenin axis by down-regulating miR-25-3p expression, inhibit the Wnt/-catenin signaling pathway, and exert anti-tumor effects (240)

Matches Phase III exposure

Intestinal translocated LPS to the portal vein is known to contribute to obesity-induced low-grade inflammation and insulin resistance in mice (193), whereas SCFAs counteract these pathogenic processes