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Clinical formulations typically incorporate appropriate antioxidant buffers or maintain GHK-Cu concentrations within therapeutic windows (0.1-10 M) to optimize beneficial effects while minimizing pro-oxidant risks

Past and ongoing trials have tested therapies targeting inflammatory signalling (IL-1 receptor antagonist, TNF- inhibitor, and toll-like receptor-4 [TLR-4] inhibitor)

10.1016/j.addr.2018.04.017 54 ClouetJ.GrimandiG.Pot-VaucelM.MassonM.FellahH

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Traditional therapies usually consist of exogenous testosterone administration, which, however, often interferes with natural hormonal regulation

The findings were published in Biochemical and Biophysical Research Communications under the title describing a tripeptide in human serum that prolongs survival of normal liver cells and stimulates growth in neoplastic liver tissue, marking the formal entry of GHK-Cu into the scientific literature