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The acetyl group allows acetyl-l-carnitine to cross into cells and mitochondria more easily

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10.1016/j.ejphar.2020.173535 43 HoofnagleJ

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reported that CB-839 could promote the production of reactive oxygen species (ROS) in colorectal cancer cells, cause nuclear translocation of Nrf2, and subsequently upregulate the expression of uridine phosphorylase 1 (UPP1), which promotes the activation of 5-fluorouracil (5-FU)

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