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We have identified a family of chloroacetamide-containing compounds with potent inhibitory activity against GSTO1 and efficacy against cancer cells in both in vitro and in vivo models

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doi: 10.1038/s44298-025-00110-3 65 KimS

Mechanistically, glutathione peroxidase 4 and ferrous iron, which are pivotal ferroptosis regulators, were upregulated in residual cells or tumors, and were hence potential therapeutic targets of persister cells

GSSG is the oxidised form two GSH molecules joined together by a disulphide bond (-S-S-) between their two cysteine sulphurs

However, and paradoxically, long-term glutaminolysis activation during nutritional restriction induces an unbalanced activation of mTORC1 during nutrient deprivation and promotes apoptosis [92]