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Moreover, this pathway is implicated in cell proliferation and survival, demonstrated by constitutively active NF-B signaling in many tissues ( FIGURE 1 The non-canonical NF-B pathway ( Figure 1 ), can be triggered by the activation of members of the TNF-receptor superfamily including B cell activating factor (BAF), belonging to the TNF family receptor, CD40, lymphotoxin (LT) receptor, and receptor activator of NF-B (RANK)