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doi: 10.1111/j.1753-4887.1998.tb01670.x 10 GuoYBrunoRS

and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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This process can be impaired when the pancreas does not produce enough digestive enzymes

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For resection-bed management in gastric cancer, the transferable rule is clear: a fast-releasing cytotoxic component plus a slow-releasing anti-inflammatory or anti-migratory modulator, matched to the perioperative high-risk window rather than a single burst dose