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Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment

MAT2A enhances aerobic glycolysis of OS through PARNAKT signaling To further investigate whether MAT2A regulates glycolysis in osteosarcoma (OS) cells via PARN-mediated signaling, we performed a series of rescue experiments

DOI: 10.1016/j.scitotenv.2023.161892

Careful monitoring, conservative scheduling, and disciplined records are what make the safety profile interpretable

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All three strains grew equally well following supplementation with isotopically light GSH or [ 13 C 2 , 15 N 1 ]-GSH (S4 and S5 Figs), suggesting that neither cysteine, glycine, nor glutamate were limiting under the tested conditions