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38,39,40 The phenotype observed after GLP-1R knockout (KO) includes various physiological and metabolic changes

Epigenetic modifications, such as DNA methylation of pro-inflammatory cytokine genes (TNF-, IL-6, and IL-1), further influence RA progression, suggesting targets for nanotechnology-based gene regulation and therapeutic intervention (11)

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Maintaining regular medical care and cancer screening regardless of peptide use represents the most important safeguard

Notably, concentrations of spermidine with demonstrated health-promoting effects can be naturally found in multiple food sources, as presented in Fig

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