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In 2011, the transmembrane glycoprotein CD44, a cancer stem-like cell marker, and more precisely the CD44 variant (CD44 v ) capable to bind hyaluronan has also been described to interacts and stabilizes system (Figure 1)

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It arises from an abnormally expanded CAG trinucleotide repeat encoding the elongated polyglutamine (polyQ) within exon 1 of Huntingtin ( HTT ) gene, which results in the production of toxic mutant huntingtin proteins (mHTT) that accumulate in neurons, particularly in the striatum and cortex ( HTT gene normally contains 10 to 35 CAG trinucleotide repeats, while HD patients exhibit more than 36 repeats

Abbaoui A, El Hiba O, Gamrani H (2016) Copper poisoning induces neurobehavioral features of Parkinsons disease in rat: Alters dopaminergic system and locomotor performance