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For the heart rate, at time points 0 and 10 min after administration there were no significant differences between the groups, while later on there were significant differences between Mel and Dex groups: patients receiving Dex by any route of administration had lower heart frequencies (after 10 and 60 min, p = 0.003

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This is the opposite of the intended therapeutic effect

Animal rooms were maintained at 22 1 C with 50% relative humidity and a 12-h light/12-h dark cycle