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Itaconate inhibits ferroptosis of macrophage via nrf2 pathways against sepsis-induced acute lung injury

Ingredients (per capsule)

As an in vivo proof-of-principle to study the role of neutrophil ferroptosis and GPX4 dysregulation, the authors generated myeloid-specific GPX4-haploinsufficient mice

The lack of in-depth investigation into redox homeostasis regulation limits the appropriate clinical application in multiple aspects with medication dose range as the main concern

A four-year study in individuals with metabolic disorders found no significant increase in adverse events with higher doses compared to lower ones.36 Who should consider ALA supplements and who shouldnt