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The present study focuses on the case of HF with reduced ejection fraction (HFrEF), a condition associated not only with a structural and mechanical deficit but also with an increased likelihood for the occurrence of life-threatening arrhythmias 7,9

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This regulatory cascade is initiated by phosphate priming at S114 within the hinge region of NHR-49, which facilitates subsequent phosphorylation at S117 and S120 by KIN-19