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On an experimental day, cells were first glucose-starved in KRB (0 mM glucose) for 1 h (37 C, 5% CO 2 ), followed by glucose stimulation with KRB supplemented with 20 mM glucose in the presence or absence of drugs for 90 min (37 C, 5% CO 2 )

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Additional Resources Semaglutide Clinical Trial New England Journal of Medicine Tirzepatide Clinical Trial New England Journal of Medicine Medically authored by Dr