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Moreover, by targeting inflammatory pathways such as NF-B and HIF-1, and reducing pro-inflammatory cytokines, mainly IL-6 and TNF-, these compounds protect against melanocyte loss characteristic of this disorder 150,151

17 When patients have failed one or more advanced medical therapies, it is appropriate to consider the option of surgical management, as it can provide many patients with good long-term quality of life, without need for medical therapy

Palmitoyl tripeptide-5 and derivatives Several derivatives have been developed in the 2000s-2010s: Palmitoyl tripeptide-1 (Pal-GHK): combination of native GHK with a palmitic chain for improved topical penetration Palmitoyl tripeptide-5 (Pal-KVK): TGF- growth factor mimetic, documented as collagen inducer Palmitoyl tetrapeptide-7 (Pal-GQPR): studied for cutaneous anti-inflammatory effect These variants all exploit the same principle: short signal peptide + lipid chain for improved membrane penetration while preserving biological activity

Jamtsho T et al

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The identification of MDR-selective compounds, particularly those with metal chelator structures, highlights a fascinating aspect of overcoming MDR in cancer cells(Szakcs et al