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Additionally, some studies found no significant cognitive benefits from metformin treatment in dementia prevention

Librero J

Next, fresh RPMI-1640 medium was used to culture cells for additional 7 days

This phenotype suggests that Cse / mice, even on standard chow, exhibit a basal ISR driven by Gcn2 , as evidenced by the mild increase in ISR genes such as Asns in the liver (Supplementary Table 2)