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Scherholz ML, Schlesinger N, Androulakis IP (2019) Chronopharmacology of glucocorticoids

It experimentally induced inflammatory reactions in the rat with the interference of eicosanoid formation in the arachidonic acid cascade (124) and could modulate the immune system as an anti-inflammatory factor ( Habashi and co-authors have also reported that bromelain potentially exerted anti-inflammatory effects by reducing nitric oxide synthesis in vitro without cytotoxicity (137)

doi: 10.3390/cells10030515 128 GuptaUGhoshSWallaceCTShangPXinYNairAPet al

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Crosby P, Hamnett R, Putker M, Hoyle NP, Reed M, Karam CJ, Maywood ES, Stangherlin A, Chesham JE, Hayter EA, Rosenbrier-Ribeiro L, Newham P, Clevers H, Bechtold DA, ONeill JS (2019) Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time