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B., Capuron, L., & Kennedy, D

Maternal autoimmune diseases have been suggested as a trigger for developmental central nervous system deficiencies as well as ASD (Han et al., 2021)

Indeed, the study of Al-Askar et al., investigated the effect of curcumin (non-botanical source

doi: 10.1111/jdv.17079 88

Carter says

Additionally, BTX may exhibit anti-nociceptive properties by down-regulating voltage-gated sodium channels, as demonstrated in a rat model of trigeminal neuralgia, or by diminishing the peripheral release of neurotransmitters such as substance P and CGRP, along with the pro-inflammatory cytokine IL-1 (101103)