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S.FreerL.GrissomC

Authors contributions AL: conceptualization, writingoriginal draft, FA: writingoriginal draft

Ferroptotic tubular cells release DAMPs (e.g., HMGB1) and lipid peroxidation products (e.g., 4-HNE), which activate pattern recognition receptors on macrophages and neutrophils, inducing the secretion of pro-inflammatory cytokines (e.g., IL-33 and MCP-1)

We obtained a total of seven major groups of cells, which were dopaminergic neurons, non-dopaminergic neurons, astrocytes, oligodendrocytes, OPCs, endothelial cells/pericytes and microglia/macrophages