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Review Song E, Su C, Fu J, Xia X, et al

Both spermine and spermidine produce toxic metabolites including acrolein and hydrogen peroxide (H 2 O 2 ) as byproducts following oxidation by bovine serum amine oxidase present in fetal bovine serum (FBS) of cell culture systems 42

CNS redox homeostasis and dysfunction in neurodegenerative diseases

Briefly, the turnover rate of metabolite i ( i ) obtained using flux-sum analysis is given by Amino acid auxotrophic simulations were performed by setting each amino acid uptake rate to zero, individually, while maximizing the growth cellular objective