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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models

doi:10.1038/s41598-017-14071-y

Glutathione, often recognized for its powerful antioxidant properties, is commonly used in various treatment modalities beyond its primary indications

Additionally, data on the use of GLP-1 therapies in geriatric populations remain limited

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