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GST Tag Cross-Reactivity Challenge : The GST tag can sometimes exhibit cross-reactivity with other proteins or reagents, leading to non-specific binding in assays and purification steps

One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)