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Notably, miR-146a is upregulated in astrocytes and their EVs in response to inflammatory stimuli, subsequently regulating key signaling pathways such as nuclear factor kappa-B (NF-B) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) to control cytokine production and immune activation [122,123]

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The studies leveraged by these companies are generally poorly designed, utilize different dosages, do not specify forms, wrong outcome measures, single dose, etc