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However, the threshold for what constituted the original disorder differs, with dependence requiring evidence of physiological dependence that abuse does not

This is one reason gentle handling is emphasized

As genotoxic treatment is clinically very effective but also toxic, we tested whether DPI could reduce the dosage of vincristine required for efficient cancer cell killing

Vet Clin North Am Small Anim Pract 40(3), 393-407

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Drug interactions Some of the possible drug interactions are: Antibiotics: vitamin c can increase the absorption of antibiotics such as tetracyclines and fluoroquinolones, which may decrease their effectiveness