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Most real-world practice trends toward under-PEEPing, unknowingly leaving the lung on the left limb of the curve, where hidden derecruitment injury accumulates breath by breath

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These metabolites can enhance lipid peroxidation by serving as substrates for further oxidative reactions or by modulating the activity of other enzymes involved in lipid metabolism

The state of hepatic GH resistance in anorexia nervosa is further corroborated by the lack of increase in IGF-I following administration of supraphysiological doses of exogenous GH in women with anorexia nervosa (61), and only refeeding appears to able to restore IGF-I levels (56, 59, 62)

It has been well documented that sepsis occurs because of over-activated immune responses which include intractable inflammatory responses associated with imbalanced cytokine production (56, 57)