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Some regions tolerate sales while others crack down, creating a patchwork legal landscape

Food and Drug Administration (FDA) Commissioner and the Center for Tobacco Products (CTP) Director stated in 2017, Nicotine, though not benign, is not directly responsible for the tobacco-caused cancer, lung disease, and heart disease that kill hundreds of thousands of Americans each year

Tobacco use accounts for at least 30 percent of all cancer deaths in the United States, according to the American Cancer Society

[22] In the United States, the most common causes of burns are: fire or flame (44%), scalds (33%), hot objects (9%), electricity (4%), and chemicals (3%)

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Zhang B, Huang R, Yang D, Chen G, Chen Y, Han J, Zhang S, Ma L, Yang X